Conceps at RWTH Aachen

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Patient case with AML

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Types of leukemias

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Difference chronic vs.acute leukemia  differentiation
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Generally Difference chronic vs.acute leukemia

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How to tell lymphoid from myeloid leukemias?

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what causes leukemias

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Radiation and Leukemia
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model disease  of cancer

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types PCR

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functional subunits of the kidney

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symptomes of Leukemie
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What do to in patient case?

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Exemplary flashcards for Conceps at the RWTH Aachen on StudySmarter:

Conceps

Patient case with AML
Diagnosis of Acute Myeloid Leukemia (AML)
further tests
recommended treatement is intensive chemitherapy with curative intention

Conceps

Types of leukemias
Lymphoid: acute (ALL), chronic (CLL)
myeloid: acute (AML), chronic (MDS,MPN [inkl. CML], MDS/MPN, PDGFR/FGFR-rearraged)

Conceps

Difference chronic vs.acute leukemia  differentiation
chronic: chronic phase (stem cell disease)--> Differentiation intact (Apoptosis sinkt, proliferation steigt)

acute: blast crisis/AML ( Progenitor cell disease)--> differentiation block ( TFs sinken)

Conceps

Generally Difference chronic vs.acute leukemia
chronic phase: ( stem cell disease)--> clinically patient still enough granolcytes to fight of bacteria, enough erythocytes to maintain O2 transport, and enough platelets to stop bleeding

acute: (Progenitor cell disease)--> clinically patient now develops systemic infections(lack granulocytes) weakness due to anemia ( lacks erythroctes) and severe bleeding (lack platelets)

Conceps

How to tell lymphoid from myeloid leukemias?
Morphology--> impossible to differentiate based only on morphology
flow cytometry

Conceps

what causes leukemias
radiation, chemical exposure, previous chemotherapy, genetic conditions

infections, race, smoking

Conceps

Radiation and Leukemia
first 10 years of radiation exposure: Leukemia
direkt and indirekt radiation: most of cancers after 5 to 10 years after atom bomb, leukemia faster

Conceps

model disease  of cancer
CML

Conceps

types PCR
qualitative and quantitative

Conceps

functional subunits of the kidney
Nephrons

Conceps

symptomes of Leukemie
cold, antibiotics did not help, fells ill, fever, weakness

Conceps

What do to in patient case?
medical history
clinical examination
blood tests

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Signaltransduktion

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Allgemeinwissen

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Controllin at

Fachhochschule Lübeck

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Universität Duisburg-Essen

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FernUniversität in Hagen

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Universität zu Lübeck

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