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Complications of chemotherapy and irradiation include:
mucositis, hemorrhage, xerostomia, periodontal inflammation, recurrent herpes simplex virus infection and bacterial and fungial infections.
decrease in the total number of leukocytes under 4.000 - 4.500/mm³.
Leukopenia
Low total circulating neutrophil count.
Neutropenia
Decreased production of neutrophils is associated with
• deficiencies of vitamin B12 and folic acid, • aplastic anemia, • tumors, • drugs, • metabolic diseases , • nutritional deficiencies (malnutrition, copper deficiency), • radiation injury, • immune mechanisms, and • heritable genetic aberrations (congenital neutropenia, cyclic neutropenia).
most common oral complications related to neutropenia are
ulcers, severe gingivitis and periodontitis.
a profound decrease or an absolute lack of circulating granulocytes, classically resulting in a neutrophil count.
Agranulocytosis
most common oral mucosal reactions to drug-induced agranulocytosis.
Gingival necrosis and oral ulceration, along with infectious pharyngitis and tonsilitis
The gingival and palatal lesions are covered by a grayish membrane in which disorder
Agranulocytosis
n increase in the number of leukocytes in the blood.
Leukocytosis
Drugs commonly associated with leukocytosis:
corticosteroids, lithium and beta agonists.
The normal haemostasis process involves three stages:
Vascular spasm 2. Platelet plug formation: p
3. Clotting
hematological disorder which is caused by proliferating white blood cell-forming tissues resulting in a marked increase in circulating immature or abnormal White blood cells.
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