B10 - Pharmacology at Medizinische Universität Wien | Flashcards & Summaries

Lernmaterialien für B10 - Pharmacology an der Medizinische Universität Wien

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TESTE DEIN WISSEN

The patient takes some aspirin. What will happen in his body?

                       

A) An enzyme will be inhibited

B) An enzyme will be activated

C) No enzyme will be affected

                                               


           

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TESTE DEIN WISSEN

A) An enzyme will be inhibited

Lösung ausblenden
TESTE DEIN WISSEN

            

                                                           

Can you think of several properties of an ideal drug?

                                               


           

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TESTE DEIN WISSEN
  • specific molecular size, shape, and charge to interact with the receptor.
  • able to travel to its site of action from its location of administration.
  • easily excreted from the body once it completes its action
  • Good effectiveness
  • safety for the living body 
  • Specificity (few adverse effects)

                                               


           

Lösung ausblenden
TESTE DEIN WISSEN

What is a drug? 

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TESTE DEIN WISSEN

Substance with a physiological effect 

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TESTE DEIN WISSEN

What is the efficacy of a drug? 

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TESTE DEIN WISSEN

Capacity to produce an effect in the body 

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TESTE DEIN WISSEN

What are typical drug target sites? 

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TESTE DEIN WISSEN
  • Molecular receptors (ligand-gated, GPCRs, enzyme-coupled receptors, nuclear receptor) 
  • DNA
  • Enzymes 
  • Solute Carrier Proteins (electrolyte transporter and neurotransmitter transporter) 
  • Others 
Lösung ausblenden
TESTE DEIN WISSEN

What is a mixed agonist-antagonist? 

Lösung anzeigen
TESTE DEIN WISSEN

            

                                                           

Mixed agonist-antagonist -> agonist for one type of receptor while working as an antagonist for another type of receptor e.g. Buprenorphine

                                               


           

Lösung ausblenden
TESTE DEIN WISSEN

            

                                                           

Activation of the GABA-A receptor increases the conduction of chloride, therefore it is a...

                                          

  1. a)  Ligand-gated ion channel       b)  G-protein-coupled receptor   c)  Enzyme-coupled receptord)  Nuclear receptor
  2.                             
  3.                         

                                               


           

Lösung anzeigen
TESTE DEIN WISSEN

a)  Ligand-gated ion channel  

Lösung ausblenden
TESTE DEIN WISSEN

            

                                                           

Is it true that antagonists trigger a conformational change of receptors?

                                               


           

Lösung anzeigen
TESTE DEIN WISSEN

NO! 

Lösung ausblenden
TESTE DEIN WISSEN

What is the pharmacodynamic of naloxone?

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TESTE DEIN WISSEN

            

                                                           

Naloxone is a non-selective and competitive opioid receptor antagonist used to reverse opioid overdose

                                               


           

Lösung ausblenden
TESTE DEIN WISSEN

What is the pharmacodynamic of flumazenil?


Lösung anzeigen
TESTE DEIN WISSEN

            

                                                           

Flumazenil is a competitive GABAA receptor antagonist and is used as a treatment of benzodiazepine overdose

                                               


           

Lösung ausblenden
TESTE DEIN WISSEN

What is the pharmacodynamic of propranolol? 


Lösung anzeigen
TESTE DEIN WISSEN

            

                                                           

Propranolol is a competitive antagonist of the beta adrenergic receptors (beta blocker) used as antihypertensive

                                               


           

Lösung ausblenden
TESTE DEIN WISSEN

            

                                                           

Pharmacodynamics studies:

                       

A) How the drug is metabolised         B) What the drug does to the body

C) How the drug is absorbed by the body

                                               


           

Lösung anzeigen
TESTE DEIN WISSEN

B) What the drug does to the body

Lösung ausblenden
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Q:

The patient takes some aspirin. What will happen in his body?

                       

A) An enzyme will be inhibited

B) An enzyme will be activated

C) No enzyme will be affected

                                               


           

A:

A) An enzyme will be inhibited

Q:

            

                                                           

Can you think of several properties of an ideal drug?

                                               


           

A:
  • specific molecular size, shape, and charge to interact with the receptor.
  • able to travel to its site of action from its location of administration.
  • easily excreted from the body once it completes its action
  • Good effectiveness
  • safety for the living body 
  • Specificity (few adverse effects)

                                               


           

Q:

What is a drug? 

A:

Substance with a physiological effect 

Q:

What is the efficacy of a drug? 

A:

Capacity to produce an effect in the body 

Q:

What are typical drug target sites? 

A:
  • Molecular receptors (ligand-gated, GPCRs, enzyme-coupled receptors, nuclear receptor) 
  • DNA
  • Enzymes 
  • Solute Carrier Proteins (electrolyte transporter and neurotransmitter transporter) 
  • Others 
Mehr Karteikarten anzeigen
Q:

What is a mixed agonist-antagonist? 

A:

            

                                                           

Mixed agonist-antagonist -> agonist for one type of receptor while working as an antagonist for another type of receptor e.g. Buprenorphine

                                               


           

Q:

            

                                                           

Activation of the GABA-A receptor increases the conduction of chloride, therefore it is a...

                                          

  1. a)  Ligand-gated ion channel       b)  G-protein-coupled receptor   c)  Enzyme-coupled receptord)  Nuclear receptor
  2.                             
  3.                         

                                               


           

A:

a)  Ligand-gated ion channel  

Q:

            

                                                           

Is it true that antagonists trigger a conformational change of receptors?

                                               


           

A:

NO! 

Q:

What is the pharmacodynamic of naloxone?

A:

            

                                                           

Naloxone is a non-selective and competitive opioid receptor antagonist used to reverse opioid overdose

                                               


           

Q:

What is the pharmacodynamic of flumazenil?


A:

            

                                                           

Flumazenil is a competitive GABAA receptor antagonist and is used as a treatment of benzodiazepine overdose

                                               


           

Q:

What is the pharmacodynamic of propranolol? 


A:

            

                                                           

Propranolol is a competitive antagonist of the beta adrenergic receptors (beta blocker) used as antihypertensive

                                               


           

Q:

            

                                                           

Pharmacodynamics studies:

                       

A) How the drug is metabolised         B) What the drug does to the body

C) How the drug is absorbed by the body

                                               


           

A:

B) What the drug does to the body

B10 - Pharmacology

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