Biochemistry at Medical University Varna

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which one of the following statements concerning urea is correct ?


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A 2-week-old infant is diagnosed with a urea cycle defect. Enzymic analysis showed
no activity for ornithine transcarbamoylase (OTC), an enzyme of the cycle. Molecular
analysis revealed that the messenger RNA (mRNA) product of the gene for OTC was
identical to that of a control. Which of the techniques listed below was most likely
used to analyze mRNA?

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How enters nitrogen in the body?

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which are the two major enzyme systems that are responsible for degrading proteins?

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can Nitrogen be stored?

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are amino acids stored in the body ?

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what is the most important way for Nitrogen to enter the body?

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How leaves Nitrogen the body?

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name the sources for amino acids 

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how are amino acids depleted ? (aufgebraucht)?

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which are the 2 major systems for protein degradation?


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A newborn with a defect in ornithine trans- carbamoylase is being fed with essential amino acids, as well as drugs to promote ammonium excretion were adminstered. To reduce ammonium ions  (NH4+) concentration you should: 

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Exemplary flashcards for Biochemistry at the Medical University Varna on StudySmarter:

Biochemistry

which one of the following statements concerning urea is correct ?


the alfa- amino group of arginine forms one of the nitrogens of urea

Biochemistry

A 2-week-old infant is diagnosed with a urea cycle defect. Enzymic analysis showed
no activity for ornithine transcarbamoylase (OTC), an enzyme of the cycle. Molecular
analysis revealed that the messenger RNA (mRNA) product of the gene for OTC was
identical to that of a control. Which of the techniques listed below was most likely
used to analyze mRNA?

Dideoxy chain termination 

Biochemistry

How enters nitrogen in the body?

Nitrogen enters the body in a variety of compounds present in food, the most
important being amino acids contained in dietary protein.

Biochemistry

which are the two major enzyme systems that are responsible for degrading proteins?

The adenosine triphosphate (ATP)-dependent, cytosolic, selective ubiquitin– proteasome and ATP-independent, nonselective lysosomal acid hydrolases are the two major enzyme systems that are responsible for degrading proteins.

Biochemistry

can Nitrogen be stored?

No

Biochemistry

are amino acids stored in the body ?

Amino acids are not stored in the body 

• must be obtained from diet, synthesis de novo or produced from normal protein degradation

Biochemistry

what is the most important way for Nitrogen to enter the body?

amino acids from diet are the most important way for Nitrogen entering the body

Biochemistry

How leaves Nitrogen the body?

leaves the body as urea, ammonia, and other products derived from amino acid metabolism

Biochemistry

name the sources for amino acids 

1. degradation of body proteins
2. derived from dietary proteins
3. synthesis of nonessential amino acids from simple intermediates of metabolism

Biochemistry

how are amino acids depleted ? (aufgebraucht)?

1. synthesis of body protein
2. amino acids consumed as precursors of essential nitrogen-containing small
molecules
3. conversion of amino acids to glucose, glycogen, fatty acid, ketone bodies, or
CO2 + H2O

Biochemistry

which are the 2 major systems for protein degradation?


for protein degradation there are two major systems:
• ATP-dependent ubiquitin-proteasome system of cytosol
• ATP-independent degradative enzyme system of lysosomes
-proteasomes degrade mainly endogenous proteins
—>proteins within the cell
- Lysosomal enzymes degrade primarily extracellular proteins

Biochemistry

A newborn with a defect in ornithine trans- carbamoylase is being fed with essential amino acids, as well as drugs to promote ammonium excretion were adminstered. To reduce ammonium ions  (NH4+) concentration you should: 

administer sodium benzoate 

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