PATHOLOGY S1 at Mansoura University | Flashcards & Summaries

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Lernmaterialien für PATHOLOGY S1 an der Mansoura University

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types of reversible cell injury?

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  • cloud swelling
  • vacuolar & hydropic degeneration
  • fatty change
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failure of inflammatory reactions lead to?

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  • infection spreads out in body
  • wounds wouldn't heal properly
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what is necrosis?

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death of group of cells in living body

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what are the main inflammatory cells in acute inflammation?

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neutrophils

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what is apoptosis?

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programmed single cell death based on activation of suicide pathway enzymes

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what is fatty change?

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intracellular accumulation of excess natural fat (triglycerides) in parenchymatous organs

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explain pathogenesis of cell injury?

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  1. mitochondrial oxidative phosphorylation is disrupted
  2. decreased ATP
  3. decreased Na-K pump
  4. increase intracellular Na
  5. cell swelling
  6. altered metabolism
  7. depletion of glycogen (anaerobic respiration with glycogenolysis)
  8. lactic acid accumulation
  9. decrease pH
  10. increases intracellular osmotic pressure
  11. cell swelling
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​2 factors that characterize irreversibility of cell damage?

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  • irreversible mitochondrial damage
  • increased intracellular Ca that activates enzyme (protease, phospholipase, endonuclease)
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types of apoptosis?

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  • physiological : during menstruation
  • pathological : viral hepatitis
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types of irreversible cell injury?

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  • ​necrosis
  • apoptosis
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types of necrosis?

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  1. coagulative necrosis (heart & kidney ischaemia)
  2. liquefactive necrosis (abscess & brain)
  3. caseation necrosis (tuberculosis / TB)
  4. fat necrosis (traumatic)
  5. fibrinoid necrosis (blood vessel disease)
  6. zenker's necrosis (typhyoid fever)
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what is vacuolar & hydropic degeneration?

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advanced stage of cloudy swelling characterized by excess water accumulation inside cells in form of cytoplasmic vacuoles (vacuolar) or large spaces (hydropic)

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  • 1 Lernmaterialien

Beispielhafte Karteikarten für deinen PATHOLOGY S1 Kurs an der Mansoura University - von Kommilitonen auf StudySmarter erstellt!

Q:

types of reversible cell injury?

A:
  • cloud swelling
  • vacuolar & hydropic degeneration
  • fatty change
Q:

failure of inflammatory reactions lead to?

A:
  • infection spreads out in body
  • wounds wouldn't heal properly
Q:

what is necrosis?

A:

death of group of cells in living body

Q:

what are the main inflammatory cells in acute inflammation?

A:

neutrophils

Q:

what is apoptosis?

A:

programmed single cell death based on activation of suicide pathway enzymes

Mehr Karteikarten anzeigen
Q:

what is fatty change?

A:

intracellular accumulation of excess natural fat (triglycerides) in parenchymatous organs

Q:

explain pathogenesis of cell injury?

A:
  1. mitochondrial oxidative phosphorylation is disrupted
  2. decreased ATP
  3. decreased Na-K pump
  4. increase intracellular Na
  5. cell swelling
  6. altered metabolism
  7. depletion of glycogen (anaerobic respiration with glycogenolysis)
  8. lactic acid accumulation
  9. decrease pH
  10. increases intracellular osmotic pressure
  11. cell swelling
Q:

​2 factors that characterize irreversibility of cell damage?

A:
  • irreversible mitochondrial damage
  • increased intracellular Ca that activates enzyme (protease, phospholipase, endonuclease)
Q:

types of apoptosis?

A:
  • physiological : during menstruation
  • pathological : viral hepatitis
Q:

types of irreversible cell injury?

A:
  • ​necrosis
  • apoptosis
Q:

types of necrosis?

A:
  1. coagulative necrosis (heart & kidney ischaemia)
  2. liquefactive necrosis (abscess & brain)
  3. caseation necrosis (tuberculosis / TB)
  4. fat necrosis (traumatic)
  5. fibrinoid necrosis (blood vessel disease)
  6. zenker's necrosis (typhyoid fever)
Q:

what is vacuolar & hydropic degeneration?

A:

advanced stage of cloudy swelling characterized by excess water accumulation inside cells in form of cytoplasmic vacuoles (vacuolar) or large spaces (hydropic)

PATHOLOGY S1

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