Pharmakologie at LMU München

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Nebenwirkungen Clonidin

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Indikationen alpha Methyldopa

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Wirkungsmechanismus LSD (Lysergsäurediethylamid)
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Wirkungsmechanismus Clonidin

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Wirkungsmechanismus Dobutamin 

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Fenoterol

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Nebenwirkungen alpha Methyldopa
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Antidot Überdosierung alpha Adrenozeptor Antagonisten

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Nebenwirkungen Theophyllin (Methylxanthin)

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Wirkungsmechanismus Reserpin (ZNS gängig)

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Indikation Guanethidin (nicht ZNS gängig)
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Cephalosporin 1. Gen

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Exemplary flashcards for Pharmakologie at the LMU München on StudySmarter:

Pharmakologie

Nebenwirkungen Clonidin
- initialer Blutdruckanstieg: periphere postsynaptische alpha 1
(bei schneller i.v.A)
- Müdigkeit, Sedierung
- Mundtrockenheit, Obstipation etc.: präsynaptische Adrenozeptoren an cholinergen Neuronen
- Rebound Hypertonie

Pharmakologie

Indikationen alpha Methyldopa
1) Schwangerschaftshypertonie (orale Langzeittherapie)
2) Hypertonie (Mittel 2. Wahl )

Pharmakologie

Wirkungsmechanismus LSD (Lysergsäurediethylamid)
partieller Agonist an 5HT2A 

Pharmakologie

Wirkungsmechanismus Clonidin
Bindung an alpha 2 Rezeptoren
- zentral: Verminderung Aktionspotenzialfrequenz des Sympathikus
- Niere: Verminderung der Renin Ausschüttung durch beta 1 (dennoch über alpha 2!)

Pharmakologie

Wirkungsmechanismus Dobutamin 
beta 1 > beta 2: positiv chrono-, dromo-, bathmo-, lusi-, inotrop

alpha 1: positiv inotrop auf Arbeitsmyokard



Pharmakologie

Fenoterol
Sympathomimetikum

Indikation: Tokolyse

Rezeptoren: beta 2 > beta 1 (keine beta 2 selektiven vorhanden!)

Einschränkung: erhöhte Herzfrequenz Mutter und Kind

Pharmakologie

Nebenwirkungen alpha Methyldopa
- wie Clonidin
- Na und Wasser Retention
- Parkinsonismus
- Depression
- hämolytische Anämie -> Coombs Test positiv 

Pharmakologie

Antidot Überdosierung alpha Adrenozeptor Antagonisten
1) Noradrenalin
2) Schocklagerung, Volumensubstitution

Cave:
Adrenalinumkehr bei Gabe von Adrenalin -> weitere Blutdrucksenkung!


Pharmakologie

Nebenwirkungen Theophyllin (Methylxanthin)
Cave: geringe therapeutische Breite!

- Tachykardie, Arrhytmie
- Tremor, Krampfanfälle
- Unruhe, Schlaflosigkeit
- Übelkeit, Erbrechen

Pharmakologie

Wirkungsmechanismus Reserpin (ZNS gängig)
Antisympathotonikum:
Hemmung der Wiederaufnahme von Noradrenalin und Dopamin in Speichervesikel, dadurch vermehrter Abbau, verminderte Neusynthese

-> Senkung Blutdruck

Pharmakologie

Indikation Guanethidin (nicht ZNS gängig)
1) Hypertonie: Kombinationstherapie mit Diuretikum 

Pharmakologie

Cephalosporin 1. Gen

  • Cefalexin
  • Cefaclor
  • Cefadroxil
  • Cefazolin


M: Peptidoglykan Synthese Hemmung

I: leichte Infektionen (CAP, Wuninfekt) (Ersatz für Penicillin G unverträglichkeit)

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LMU München

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