General Pathology at LMU München

Reduced tissue blood flow/ perfusion → low o2, low nutrients, accumulation of metabolites (ischaemic core is necrotic, ischemic penumbra (if partial occlusion surrounds it)

lower body temperature (ears-skin-head-extremities-viscera)

o2 on erys decreased (acute/chronic)

clear fluid in alveolar lumen

Arterial Thrombus - White, 

Venous Thrombus -Red

=Intravascular mass circulating and obstructing blood/lymphatic vessels

→ Thrombus particles, Fat embolisms (from bone fracture, can be found in lung later due to them being in veins), Air embolism (iatrogen, chest wall injuries), Amniotic fluid embolism (parturition complications), Tumor cells, Fibro-cartilage parts (disc injury), Parasites/Bacteria

→ Can lead to bacterial endocarditis, Infarction of the kidney etc.

Therapy/ Prevention :
Aspirin → inhibits platelet aggregation, blocks AA metabolite (thromboxane)

1. Necrosis
2. Inflammation
3. Vascular changes
4. Degeneration, extracellular deposition
5. Cells adaptation (atrophy, hyperplasia, hypertrophy)
6. Tumor 7. Growth disorders

disorder/loss of function in homeostasis or organ caused by etiological agent

when disease in one organ makes it worse for the same organ in circle

Latent (1), Prodromal (2), Culmination (3), Final (4)

(1)= incubation period, first impact
(2)= early symptoms, vague appearance

(3)= expressed, typical clinical signs

(4)= Resolution (remission, chronic form, healing, death

Natural death (exitus letalis) - bye old age, organ functions depleted

Premature death - Violent (forensics, slaughter, euthanasia) Non-violent (disease)

Process of death