MolGen - Tobiasch at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg

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Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Cancer requires ______ step(s). 

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

How were oncogenes first identified? 

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Oncogenes are genetically _______. 

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Tumorsupressor genes are genetically _______. 

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Compare normal cells and cancer cells according their morphology, anchorage dependence and density dependence

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What does a mutation of the ErbB protein result in? 

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Ras is a small __________. 

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which transcription factors are activated by the Ras-Raf-Mek-ERK pathway

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name examples for tumorsuppressors!

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name an example for an oncogene!

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

How is the retinoblastoma a two-step carcinogenesis

Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which cyclins and Cdks are involved in G1 progression

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Exemplary flashcards for MolGen - Tobiasch at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

MolGen - Tobiasch

Cancer requires ______ step(s). 

only one

MolGen - Tobiasch

How were oncogenes first identified? 

They were identified because retroviruses transduced these sequences into normal cells and caused cancer in animals.

MolGen - Tobiasch

Oncogenes are genetically _______. 

dominant

MolGen - Tobiasch

Tumorsupressor genes are genetically _______. 

recessive 

MolGen - Tobiasch

Compare normal cells and cancer cells according their morphology, anchorage dependence and density dependence

Normal cells:

- flat morphology 

- anchorage dependent 

- density dependent 


Cancer cells:

- rounded morphology 

- anchorage independent 

- density independent 

MolGen - Tobiasch

What does a mutation of the ErbB protein result in? 

 It results in a constantly active tyrosine kinase, just as if it would bind a EGF (growth factor) non-stop leading to tumors

MolGen - Tobiasch

Ras is a small __________. 

GTPase

MolGen - Tobiasch

Which transcription factors are activated by the Ras-Raf-Mek-ERK pathway

- c-myc 

- c-Fos

- c-Jun 

- Ets 

MolGen - Tobiasch

Name examples for tumorsuppressors!

- Rb (retinoblastoma) gene 

- p53

MolGen - Tobiasch

Name an example for an oncogene!

- NF1 (Neurofibromatosis) Ras GAP

MolGen - Tobiasch

How is the retinoblastoma a two-step carcinogenesis

1. Step: Born with mutated gene (loss of heterozygosity). 


2. Step: UV light damage.

MolGen - Tobiasch

Which cyclins and Cdks are involved in G1 progression

CycD + Cdk2/Cdk4/Cdk5

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