Immunology 🦠 at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg

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Study with flashcards and summaries for the course Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Adaptive immune system

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Innate immune system

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

granulocytes
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Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Phagocytes

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

mast cells

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

chemical barriers

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NK cells
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Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

ß- defensins

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Cathelicidins

Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

complement system, terminal pathway

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Histatins
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Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

stages of complement action

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Exemplary flashcards for Immunology 🦠 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Immunology 🦠

Adaptive immune system
Specific Antigen recognition
 Takes 4 -5 days 
Starts in specialized organs 
Memory

Immunology 🦠

Innate immune system
Aspecific Pattern recognition
 Immediate action 
Initiation at the site of infection 
Not stronger reaction at second encounter

Immunology 🦠

granulocytes
innate immune system 
neutrophil: phagocytosis and activation of bactericidal mechanisms 
basophil: promotion of allergic responses and augmentation of anti-parasitic immunity 
eosinophil: killing of antibody- coated parasites

Immunology 🦠

Phagocytes
innate immune system 

macrophage: phagocytosis and activation of bactericidal mechanisms, antigen presentation (precursor: monocyte)
dendritic cell: antigen uptake in peripheral sites, antigen presentation
neutrophil: phagocytosis and activation of bactericidal mechanisms

Immunology 🦠

mast cells
innate immune system
 release of granules containing histamine and active agents

Immunology 🦠

chemical barriers
antimicrobial proteins - enzymes (lysozyme) -antimicrobial peptides (defensins, cathelicidins, histatins) complement system (can kill pathogens without cells)

Immunology 🦠

NK cells
natural killer cells
innate immune system
releases lytic granules that kill some virus-infected cells

Immunology 🦠

ß- defensins
- keratinocytes
 - epithelial cells urogenital/ respiratory tract

Immunology 🦠

Cathelicidins
- Epithelial cells
- Neutrophils

Immunology 🦠

complement system, terminal pathway
It starts with C5 which is cleaved into C5a and C5b (by C5 convertase). C5b is bound by C6, C7 and C8 (C7 and mainly C8 can insert into the membrane) and multiple C9. form the membrane attack complex (MAC)

Immunology 🦠

Histatins
oral cavity - pathogenic fungi

Immunology 🦠

stages of complement action
1. pattern recognition trigger
2. protease cascade amplification/ C3 convertase
3. effect (chemoattraction/Inflammation, opsonization/phagocytosis, Membrane attack)

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