Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at Hochschule Bonn-Rhein-Sieg

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Study with flashcards and summaries for the course Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What triggers T-cell activation?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What actions can be activated by T-cell activation?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name the two regions of the TCR complex.

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which two characteristics do α-chain and β-chain have in common?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

How many signals are required for activation of T cells?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name the three signals that are needed for T cell activation. 

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What can happen when the three signals of T cell activation have arrived?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which stimulation do dendritic cells need to mature?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is a major difference between immature and mature DCs?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Where does T cell activation take place?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Where can the T cell zones be found?

Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

How do T and B cells always enter the lymph nodes?

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Exemplary flashcards for Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

What triggers T-cell activation?
antigen presentation by APC

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

What actions can be activated by T-cell activation?
- cytotoxic activation (killing of infected or tumour cells)
- differentiation into types of T helper cells

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

Name the two regions of the TCR complex.
α-chain, β-chain

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

Which two characteristics do α-chain and β-chain have in common?
- both have variable and constant region
- transmembrane part that is bound to cytoplasmic membrane

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

How many signals are required for activation of T cells?
Three

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

Name the three signals that are needed for T cell activation. 
- activation signal
- co-stimulation between B7/CD80 (on APC) and CD28 (on T cell) (signals survival)
- differentiating signal (coming from cytokines)

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

What can happen when the three signals of T cell activation have arrived?
naive T cells will proliferate and differentiate into an effector T cell

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

Which stimulation do dendritic cells need to mature?
PAMP stimulation makes DCs mature from immature cells

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

What is a major difference between immature and mature DCs?
immature DCs
- capable of phagocytosing
- not capable of migration

matures due to phagocytosis
- no longer phagocytoses
- migrate to activate T cells

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

Where does T cell activation take place?
T cell zones

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

Where can the T cell zones be found?
secondary lymphoid organs, such as the lymph nodes, spleen and peyer's patches

Immunology - Chapter 8: T-cell activation in secondary lymphoid tissues

How do T and B cells always enter the lymph nodes?
through high endothelial venule (HEV)

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