Immunology - Chapter 5: Cytokines at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg

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Study with flashcards and summaries for the course Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is a cytokine?

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name the four major families of cytokines.

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name the five most important cytokines produced by macrophages after phagocytosis.

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

"The amount of cytokine released in an infection will also determine the severity of the reaction and may even cause completely different effects."

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name three examples of broad range cytokines.

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Chemokines are further subdivided into CXC and CC classes, but what does the C stand for?

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name an example for a CXC chemokine.

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name an example for a CC chemokine.

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the function of CXC chemokines?

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the function of CC chemokines?

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Leucocytes are also attracted via chemokines, but must undergo a specific process to pass the endothelium. What is this process called?

Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Explain in brief the process of rolling in terms of leucocytes passing the endothelium.

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Exemplary flashcards for Immunology - Chapter 5: Cytokines at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Immunology - Chapter 5: Cytokines

What is a cytokine?
Proteins made by a cell that affect the behaviour of other cells, particularly immune cells. Cytokines made by lymphocytes are often  called interleukins (= IL).

Immunology - Chapter 5: Cytokines

Name the four major families of cytokines.
- TNF family (e.g. TNFα)
- Haematopoietin family (e.g. IL-6)
- IL-1 family (e.g. IL-1α/β)
- Interferons (e.g. Type I)
- Chemokines (CXC, CC)

Immunology - Chapter 5: Cytokines

Name the five most important cytokines produced by macrophages after phagocytosis.
- TNF-α
- IL-1β
- IL-6
- CXCL8/IL-8
- IL-12

Immunology - Chapter 5: Cytokines

"The amount of cytokine released in an infection will also determine the severity of the reaction and may even cause completely different effects."
Right

Immunology - Chapter 5: Cytokines

Name three examples of broad range cytokines.
- IL-1β
- IL-6
- TNF-α 

Immunology - Chapter 5: Cytokines

Chemokines are further subdivided into CXC and CC classes, but what does the C stand for?
cysteines present at the N-terminus

Immunology - Chapter 5: Cytokines

Name an example for a CXC chemokine.
CXCL8

Immunology - Chapter 5: Cytokines

Name an example for a CC chemokine.
CCL2

Immunology - Chapter 5: Cytokines

What is the function of CXC chemokines?
attraction of neutrophils

Immunology - Chapter 5: Cytokines

What is the function of CC chemokines?
attraction of monocytes

Immunology - Chapter 5: Cytokines

Leucocytes are also attracted via chemokines, but must undergo a specific process to pass the endothelium. What is this process called?
Rolling

Immunology - Chapter 5: Cytokines

Explain in brief the process of rolling in terms of leucocytes passing the endothelium.
- weak binding of leukocyte to selectin
- slow travel along endothelium
- not taken by blood flow
- tight adhesion to ligands
- diapedesis
- migration to site of infection

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