Immunology - Chapter 11: B- and T-cell development at Hochschule Bonn-Rhein-Sieg

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Study with flashcards and summaries for the course Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What are the progenitors of NK-cells, B-cells and T-cells? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What does the bone marrow consist of? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What happens in the red bone marrow

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Next to red and yellow bone marrow, there are also other structures in the bone marrow. Which ones and what are their functions? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Why are stromal cells so important for B-cell development

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What does yellow bone marrow consist of and what does it do? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

B-cell development begins in the bone marrow and starts with ______? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which proteins are expressed mainly during VDJ recombination? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What takes place before the other? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Once the recombination of the heavy chain genes started, which molecule of the B-cell gets expressed? 

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What happens immediately after the production of the BCR and finished gene arrangement

Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

When the BCR is tested against self-molecules and reaction (high affinity) occurs, what happens? 

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Exemplary flashcards for Immunology - Chapter 11: B- and T-cell development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Immunology - Chapter 11: B- and T-cell development

What are the progenitors of NK-cells, B-cells and T-cells? 
Pre-NK-cells

Pre-B-cells

Thymocytes

Immunology - Chapter 11: B- and T-cell development

What does the bone marrow consist of? 
Yellow bone marrow and red bone marrow 

Immunology - Chapter 11: B- and T-cell development

What happens in the red bone marrow
- Development of lymphocytes
- Residing of stem cells 

Immunology - Chapter 11: B- and T-cell development

Next to red and yellow bone marrow, there are also other structures in the bone marrow. Which ones and what are their functions? 
1. Reticular connective tissue with stromal cells (give development signals to blood cells)
2. sinusoidal capillaries (nutritional supply)

Immunology - Chapter 11: B- and T-cell development

Why are stromal cells so important for B-cell development
They express the B-cell receptors and molecules at different stages of development 

Immunology - Chapter 11: B- and T-cell development

What does yellow bone marrow consist of and what does it do? 
- it mainly consist of adipocytes, which get increasingly large with age

- they excrete some hormone-like molecules and development signals

Immunology - Chapter 11: B- and T-cell development

B-cell development begins in the bone marrow and starts with ______? 
rearrangement of VDJ antibody genes

Immunology - Chapter 11: B- and T-cell development

Which proteins are expressed mainly during VDJ recombination? 
Rag1/2 proteins 

Immunology - Chapter 11: B- and T-cell development

What takes place before the other? 
Rearrangement of heavy chain genes VDJ

Immunology - Chapter 11: B- and T-cell development

Once the recombination of the heavy chain genes started, which molecule of the B-cell gets expressed? 
B-cell receptor 

Immunology - Chapter 11: B- and T-cell development

What happens immediately after the production of the BCR and finished gene arrangement
Testing against self-molecules 

Immunology - Chapter 11: B- and T-cell development

When the BCR is tested against self-molecules and reaction (high affinity) occurs, what happens? 
It will likely be induced to perform apoptosis

OR

it will be used to generate non-autoreactive mature B-cells by receptor editing

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