Immunology - Auto-immunity and Transplantation at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg

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Study with flashcards and summaries for the course Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is Tolerance?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which cell support tolerance?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which cell stimulate immunity?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which are the ways to create tolerance?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

How is central tolerance achieved?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is antigen segregation?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

How it peripheral tolerance achieved?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name the two types of Treg.

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Where do the two type of Treg develop?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which cytokines are produced by Treg and what is theit function?

Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What are autoimmune diseases?

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Explain SLE (systemic lupus erythematosus).

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Exemplary flashcards for Immunology - Auto-immunity and Transplantation at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Immunology - Auto-immunity and Transplantation

What is Tolerance?
ignorance of self-antigens must always be in a balance with immunity (recognition of non-self-antigens

Immunology - Auto-immunity and Transplantation

Which cell support tolerance?
Treg

Immunology - Auto-immunity and Transplantation

Which cell stimulate immunity?
APCs (antigen presenting cells)

Immunology - Auto-immunity and Transplantation

Which are the ways to create tolerance?
  • Central tolerance
  • peripheral tolerance
  • antigen segration

Immunology - Auto-immunity and Transplantation

How is central tolerance achieved?
  • B and T cell tested against self-antigens during maturation process

Immunology - Auto-immunity and Transplantation

What is antigen segregation?
some self-antigens are never accessible by lymphoid system or there is no immune system present where the antigen is found (in the brain)

Immunology - Auto-immunity and Transplantation

How it peripheral tolerance achieved?
  • suppression of activity by Treg
  • downregulation of activity by presenting weak signals

Immunology - Auto-immunity and Transplantation

Name the two types of Treg.
  • induced Treg
  • natural Treg

Immunology - Auto-immunity and Transplantation

Where do the two type of Treg develop?
  • induced: periphery
  • natural: thymus

Immunology - Auto-immunity and Transplantation

Which cytokines are produced by Treg and what is theit function?
  • IL-10
  • TGF-beta
  • Function: inhibit self-reactive T cells

Immunology - Auto-immunity and Transplantation

What are autoimmune diseases?
  • develop whne a variety of different regulatory functions are defect from genetic factors,to environmental exposure and dysregulation of the immune system
  • (non)/organ specific diseases

Immunology - Auto-immunity and Transplantation

Explain SLE (systemic lupus erythematosus).
  • immune disease
  • antibodies are produced against DNA, chromatin and ribonucleoproteins
  • (supected) caused by trauma
  • results in free floating DNA in the extracelluar space
  • could be picked up by weakly-autoreactive Bcells.
  • PRRs falsely recognize DNA as bacterial-sequence

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