Immunology: Antibodies and their use in research at Hochschule Bonn-Rhein-Sieg

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Study with flashcards and summaries for the course Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What can pepsin do to an antibody's structure? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the Fab region and what is it capable of? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is an epitope? What binds the epitope? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Is it possible, that an antibody can have different paratopes, which bind to the same antigen, but at different epitopes

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is included in the hypervariable region of an antibody? Why is this region called like that? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What are CDRs and what is their function? Where are they found? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which forces are involved in antigen-antibody interaction and complementarity? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What does affinity mean? 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What does avidity mean? 

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Mostly, the total binding strength is made up of ____ binding sites, with IgA and IgM being an exeption. 

Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Of how many binding sites can the total binding strength of IgM and IgA be made up?

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Which antibody isotype is very rare and not usually secreted

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Exemplary flashcards for Immunology: Antibodies and their use in research at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Immunology: Antibodies and their use in research

What can pepsin do to an antibody's structure? 
- It can break the disulphide bonds which connect the heavy and light chain

- this yields the antigen binding fragment (Fab region) and the crystallizable/constant fragment (Fc region

Immunology: Antibodies and their use in research

What is the Fab region and what is it capable of? 
= antigen binding fragment

capable of: 
- binding the antigen without Fc region
- neutralization 

Immunology: Antibodies and their use in research

What is an epitope? What binds the epitope? 
specific part on antigen, where top part of variable region (paratope) of antibody binds 

Immunology: Antibodies and their use in research

Is it possible, that an antibody can have different paratopes, which bind to the same antigen, but at different epitopes
Yes

Immunology: Antibodies and their use in research

What is included in the hypervariable region of an antibody? Why is this region called like that? 
- The top parts of the light and heavy chain
- parts of the paratope region
- it is called like that, because it is involved in somatic hypermutation

Immunology: Antibodies and their use in research

What are CDRs and what is their function? Where are they found? 
= complementarity determing regions

- regions of antibody that determine the compatibility of antibody to antigen
- found on both heavy and light chain 

Immunology: Antibodies and their use in research

Which forces are involved in antigen-antibody interaction and complementarity? 
Non-covalent forces like...

- electrostatic forces
- Van der Waals forces
- hydrophobic forces
- hydrogen bonds 

Immunology: Antibodies and their use in research

What does affinity mean? 
Single binding strength of one paratope to its epitope 

Immunology: Antibodies and their use in research

What does avidity mean? 
Total binding strength of an antibody 

Immunology: Antibodies and their use in research

Mostly, the total binding strength is made up of ____ binding sites, with IgA and IgM being an exeption. 
6

Immunology: Antibodies and their use in research

Of how many binding sites can the total binding strength of IgM and IgA be made up?
IgM: up to 10

IgA: up to 4 

Immunology: Antibodies and their use in research

Which antibody isotype is very rare and not usually secreted
IgM

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