Dev Bio Limb development at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg

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Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Tetrapod limbs

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Anterior posterior axis (Thumb-pinkie) is regulated by

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Proximal distal axis is regulated by

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Anterior posterior (Thumb-pinkie) is regulated by

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Dorsal ventral axis is regulated by

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Structures of the limp are derived from

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Limb skeletal precursor cells from

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Limb muscle precursor from

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

During limb formation a structure is formed that stimulates proliferation of mesenchyme and therefore linear growth

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Apical Ectodermal Ring (AER)

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Anterior posterior axis is determined by

Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Zone of polarising activity expresses

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Exemplary flashcards for Dev Bio Limb development at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Dev Bio Limb development

Tetrapod limbs
Are homologous structures; derived from same progenitor and following similar developmental pathway

Dev Bio Limb development

Anterior posterior axis (Thumb-pinkie) is regulated by
Sonic hedgehog

Dev Bio Limb development

Proximal distal axis is regulated by
Fibroblast growth factor (FGF)

Dev Bio Limb development

Anterior posterior (Thumb-pinkie) is regulated by
Sonic hedgehog

Dev Bio Limb development

Dorsal ventral axis is regulated by
Wnt7

Dev Bio Limb development

Structures of the limp are derived from
Somites, lateral plate Mesoderm, ectoderm

Dev Bio Limb development

Limb skeletal precursor cells from
Lateral plate mesoderm

Dev Bio Limb development

Limb muscle precursor from
Somites

Dev Bio Limb development

During limb formation a structure is formed that stimulates proliferation of mesenchyme and therefore linear growth
Apical Ectodermal Ridge

Dev Bio Limb development

Apical Ectodermal Ring (AER)
Stimulates proliferation of mesenchyme, allowing linear growth of limb
Expression of molecules that direct anterior posterior axis
Control dorsal ventral pathway
Induced by  Fgf10 secreted mesenchyme
Responsible for growth and development of limb
Positive Feedback loop between AER and mesenchyme

Dev Bio Limb development

Anterior posterior axis is determined by
The zone of polarising activity (ZPA)

Dev Bio Limb development

Zone of polarising activity expresses
Sonic hedgehog

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