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Dev Bio Introduction
Malformation
Abnormalities by genetic events
Dev Bio Introduction
Disruption
Abnormalitiey by exogenous agents (teratogens)
Dev Bio Introduction
Exogenous agent that leads to developmental disorders is called
teratogen
Dev Bio Introduction
Organogenesis
Formation of organs out of germ layers
starts with notochord
Dev Bio Introduction
Model organims for developmental biology
Sea urchin
Caenorhabditis elegans
Drosophila melanogaster
Danio rerio (Zebra fish)
Xenopus laevis (frog)
Gallus gallus domesticus (chicken)
Mus musculus (mouse)
Dev Bio Introduction
Preformation therory
complete miniature organism enclosed in sperm cell
Dev Bio Introduction
Epigenesis therory
Organs are formed de novo with each generation
Dev Bio Introduction
Homologous
structures derive from same ancestor
Dev Bio Introduction
Analogous
structure in two species have same function but derive from different origins
Dev Bio Introduction
2 Major cells in Embryo
Epithelial cells
Mesenchymal cells
Dev Bio Introduction
Epithelial cells
Cells are tighly connected to each other forming sheets or tubes
Dev Bio Introduction
Mesenchymal cells
cells are unconnected and work as independent units
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