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Dev Bio Gene expression
Tracing of cell lineages is used to create
fate maps
Dev Bio Gene expression
How to trace cell lineages
Direct Observation of embryo
Dye marking
Genetic labbeling
Dev Bio Gene expression
Genetic labbeling
permanent labbeling of cells and their progressors
Dev Bio Gene expression
Chimera
Individual containing cells from two different species
Dev Bio Gene expression
Genomic equivalence
Each somatic cell nucleus within an organism has identical chromosomes and same set of genes
Dev Bio Gene expression
nucleosomes can be wound into tight
solenoids
Dev Bio Gene expression
Heterochromation
Chromatin mainly in solenoid conformation, low transcription rate
Dev Bio Gene expression
Acetylation
compensates positive charge of lysines and loosens nucleosomes
activation of transcription
Dev Bio Gene expression
Methylation
can repress or activate
mainly repress
Dev Bio Gene expression
Enhancer
DNA sequence which controls efficency and rate of transcription
binds transcription factors
Can control temporal and tissue specific expression of genesDev Bio Gene expression
Enhancers are cis regulatory elements
only activate Promotor on same chromosome
Dev Bio Gene expression
Transcription factor domains
DNA binding domain
Trans activation domain
Protein-protein interaction domain
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