Cell Migration Exercise 1 at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg

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Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What are the four steps of a complete cell migration process?

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name the four different kinds of protrusions.

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Characterize filopodia as protrusions.

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Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Characterize lamellipodia as protrusions.

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Characterize stress fibers as protrusions.

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Characterize arcs as protrusions.

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What are the characteristic features of hapotactic molecules?

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Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Name examples for hapotactic molecules.

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the function of cdc42 during cell migration?

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which kind of cell migration mechanisms do you know?

Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the function of Par3?

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Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the function of Par6?

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Exemplary flashcards for Cell Migration Exercise 1 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Cell Migration Exercise 1

What are the four steps of a complete cell migration process?

  • Cell polarization
  • Protrusion
  • Traction
  • Retraction

Cell Migration Exercise 1

Name the four different kinds of protrusions.

  • Filopodia
  • Lamellipodia
  • Stress fibers
  • Arcs

Cell Migration Exercise 1

Characterize filopodia as protrusions.

  • parallel actin bundles
  • often decorated with tropomyosin and fascin

Cell Migration Exercise 1

Characterize lamellipodia as protrusions.

  • broad, sheet-like
  • branched
  • dendritic network of thin, short actin filaments

Cell Migration Exercise 1

Characterize stress fibers as protrusions.

  • thick actin filament bundles
  • antiparallel actin filaments 
  • heavily decorated with myosin II
    → contractile properties

Cell Migration Exercise 1

Characterize arcs as protrusions.

  • large actin filament bundles
    → transverse structural support for cell
  • at dorsal and side portions of the cell 

Cell Migration Exercise 1

What are the characteristic features of hapotactic molecules?

  • Surface bound chemoattractive factors
  • Promoting directed cell migration

Cell Migration Exercise 1

Name examples for hapotactic molecules.

  • Fibroblast Growth factor family (FGF)
  • Receptor PECAM1 (CD31)

Cell Migration Exercise 1

What is the function of cdc42 during cell migration?

  • Rho-family GTPase
  • induces formation of filopodia 
  • activates actin polymerization (by binding WASP)
  • reorientation of Golgi apparatus towards the leading edge 

Cell Migration Exercise 1

Which kind of cell migration mechanisms do you know?

  • Single cell migration
    → Amöboid
    → Mesenchymal
    → Mesenchymal chain migration
  • Collective cell migration

Cell Migration Exercise 1

What is the function of Par3?

  • part of PAR complex (Par3/Bazooka, Par6, aPKC)
  • regulator for asymmetric cell division and polarized growth

Cell Migration Exercise 1

What is the function of Par6?

  • Par6 (together with aPKC) plays essential role in spine morphogenesis

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