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Cell migration: Ex 6
What are the progenitor cells of microglia cells?
Myeloid progenitors in the embryonic yolk sac.
Cell migration: Ex 6
What is a specific marker for end differentiated microglial cells?
Chemokine receptor CXC3R1-GFP
Cell migration: Ex 6
Mention some chemoattractant substances for microglia cells!
Cell migration: Ex 6
What is the precursor of a monocyte and what are its characteristics?
hemangioblast stem cell
(amoeboid, CD34+)
Cell migration: Ex 6
Migrating monocytes express low levels of _______ integrins.
ß1
Cell migration: Ex 6
Entering tissues, monocytes differentiate into what? Which intergrins do they express?
Monocytes differentiate into macrophages, highly expressing ß1 and ß3 integrins.
Cell migration: Ex 6
Which genes are involved in colon tumorgenesis?
Cell migration: Ex 6
What is adenomatous polyposis? What are the symptoms and the threat?
Adenomatous polyposis is an autosomal dominant disorder.
Symptoms are the development of thousands of adenomatous polyps of the colon and rectum.
Threat is that those polyps progress to colorectal carcinoma
Cell migration: Ex 6
Ras proteins are members of the ________ family.
GTPase
Cell migration: Ex 6
Ras proteins are switches for signaling pathways for cellular processes like ... ?
Cell migration: Ex 6
What does the DCC gene encode and mediate?
- It encodes a functional receptor for netrin (NTN1)
- It mediates axon outgrowth and steering response
Cell migration: Ex 6
What does DCC stand for?
Deleted in colorectal carcinoma.
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