Cell migration: Ex 6 at Hochschule Bonn-Rhein-Sieg

Flashcards and summaries for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg

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Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What are the progenitor cells of microglia cells? 

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is a specific marker for end differentiated microglial cells?                                    

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Mention some chemoattractant substances for microglia cells!

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Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is the precursor of a monocyte and what are its characteristics? 

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Migrating monocytes express low levels of _______ integrins.

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Entering tissues, monocytes differentiate into what? Which intergrins do they express? 

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Which genes are involved in colon tumorgenesis?

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Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What is adenomatous polyposis? What are the symptoms and the threat? 

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Ras proteins are members of the ________ family. 

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Ras proteins are switches for signaling pathways for cellular processes like ... ? 

Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

What does the DCC gene encode and mediate?

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What does DCC stand for? 

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Exemplary flashcards for Cell migration: Ex 6 at the Hochschule Bonn-Rhein-Sieg on StudySmarter:

Cell migration: Ex 6

What are the progenitor cells of microglia cells? 

Myeloid progenitors in the embryonic yolk sac.

Cell migration: Ex 6

What is a specific marker for end differentiated microglial cells?                                    

Chemokine receptor CXC3R1-GFP

Cell migration: Ex 6

Mention some chemoattractant substances for microglia cells!

  • Lipopolysaccharides (LPS) 
  • Monocyte chemotactic protein (MCP-1)
  • Macrophage inflammatory peptide-1a (MIP-1a) 
  • interleukin-8

Cell migration: Ex 6

What is the precursor of a monocyte and what are its characteristics? 

hemangioblast stem cell

(amoeboid, CD34+)

Cell migration: Ex 6

Migrating monocytes express low levels of _______ integrins.

ß1

Cell migration: Ex 6

Entering tissues, monocytes differentiate into what? Which intergrins do they express? 

Monocytes differentiate into macrophages, highly expressing ß1 and ß3 integrins.

Cell migration: Ex 6

Which genes are involved in colon tumorgenesis?

  • APC 
  • K-ras
  • DCC
  • p53

Cell migration: Ex 6

What is adenomatous polyposis? What are the symptoms and the threat? 

Adenomatous polyposis is an autosomal dominant disorder.


Symptoms are the development of thousands of adenomatous polyps of the colon and rectum. 


Threat is that those polyps progress to colorectal carcinoma

Cell migration: Ex 6

Ras proteins are members of the ________ family. 

GTPase

Cell migration: Ex 6

Ras proteins are switches for signaling pathways for cellular processes like ... ? 

  • proliferation
  • differentiation 
  • survival
  • apoptosis 
  • motility 
  • phagocytosis

Cell migration: Ex 6

What does the DCC gene encode and mediate?

- It encodes a functional receptor for netrin (NTN1) 


- It mediates axon outgrowth and steering response


Cell migration: Ex 6

What does DCC stand for? 

Deleted in colorectal carcinoma. 

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