Immunology at Charles University Prague | Flashcards & Summaries

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Lernmaterialien für Immunology an der Charles University Prague

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TESTE DEIN WISSEN
Proinflammatory 
IL-18
Lösung anzeigen
TESTE DEIN WISSEN
  • increase production of IFN γ
Lösung ausblenden
TESTE DEIN WISSEN
Anti inflamm 
IL-4
Lösung anzeigen
TESTE DEIN WISSEN
    • Secreted by Th2 and basophils
    • Functions:
      • Th2 differentiation
      • Th1 inhibition
      • B-cell stimulation
      • Isotype switching to IgE and IgG4
Lösung ausblenden
TESTE DEIN WISSEN
Proinflammatory 
IL-6
Lösung anzeigen
TESTE DEIN WISSEN
    • Secreted by Th2, macrophages and neutrophils, B-cells
    • Functions:
      • T and B-cells stimulation
      • Stimulation of Ig production
      • Induction of acute phase proteins synthesis
      • Pyrogen 
Lösung ausblenden
TESTE DEIN WISSEN
Proinflammatory 
IL-12
Lösung anzeigen
TESTE DEIN WISSEN
    • Secreted by macrophages, B-cells and dendritic cells
    • Functions:
      • Th1 differentiation
      • NK stimulation
      • Cytotoxic T-cell stimulation
Lösung ausblenden
TESTE DEIN WISSEN
Proinflammatory 
Tumor Necrosis Factor 
Lösung anzeigen
TESTE DEIN WISSEN
    • Released by CT-cells, NK cells, macrophages, monocytes and also Th1
    • Function:
      • Induction of apoptosis
      • Induction of local inflammation ( ↑ T)
      • Endothelium activation
      • Chemotaxin for adhesion molecules
Lösung ausblenden
TESTE DEIN WISSEN
macrophages function 
Lösung anzeigen
TESTE DEIN WISSEN
  • Phagocytosis → inflammation
  • APC’s
  • Secrete cytokines (IFNα, IL-1) → inflammation
  • Production of lysozyme, complement component and oxygen metabolites 
  • Regulation of cellular functions
  • Production of endogenous pyrogens → fever
  • Repair of tissues 
  • Leukocytosis 
Lösung ausblenden
TESTE DEIN WISSEN
macrophages IL 
Lösung anzeigen
TESTE DEIN WISSEN
IL-1 
IFN alpha 
Lösung ausblenden
TESTE DEIN WISSEN
Proinflammatory
IL-1
Lösung anzeigen
TESTE DEIN WISSEN
    • Secreted by macrophages and neutrophils
    • Functions: 
      • T-cell costimulation
      • Induction of TNF (Tumor Necrosis Factor) and IL-8
      • Pyogen (induce fever)
Lösung ausblenden
TESTE DEIN WISSEN
Monocytes CD
Lösung anzeigen
TESTE DEIN WISSEN
CD 14
Lösung ausblenden
TESTE DEIN WISSEN
Proinflammatory 
IL-8
Lösung anzeigen
TESTE DEIN WISSEN
    • Secreted by macrophages
    • Functions:
      • Granulocyte activation
      • Main chemokine for neutrophil “calling” (chemotaxis)
Lösung ausblenden
TESTE DEIN WISSEN

Phagocytosis respiratory burst 

Lösung anzeigen
TESTE DEIN WISSEN

1. increase O2 consumption and glucose 

2. pentose phosphate pathway stimulated for synthesis of NADPH 

3. Produktion of O2 (superoxide anion)-> extremely toxic 

4. Converted to H2O2 (hydrogen peroxide) = oxidizing agent 

5. Production of O2 (singlet oxygen) and OH-(hydroxyl radical) = unstable oxidizing agents

6.Myeloperoxidases : toxic per oxidation of surface molecules > formation of HOCl (hypochlorus acid) 

7. HOcl converted to ClO- (hypochlorite) - very toxic 

8. Exocytosis 

Lösung ausblenden
TESTE DEIN WISSEN
Anti inflamm 
IL-10
Lösung anzeigen
TESTE DEIN WISSEN
    • Secreted by Th2, monocyte and Treg
    • Functions:
      • B-cell differentiation
      • Th1 and macrophage inhibition
Lösung ausblenden
  • 13101 Karteikarten
  • 446 Studierende
  • 4 Lernmaterialien

Beispielhafte Karteikarten für deinen Immunology Kurs an der Charles University Prague - von Kommilitonen auf StudySmarter erstellt!

Q:
Proinflammatory 
IL-18
A:
  • increase production of IFN γ
Q:
Anti inflamm 
IL-4
A:
    • Secreted by Th2 and basophils
    • Functions:
      • Th2 differentiation
      • Th1 inhibition
      • B-cell stimulation
      • Isotype switching to IgE and IgG4
Q:
Proinflammatory 
IL-6
A:
    • Secreted by Th2, macrophages and neutrophils, B-cells
    • Functions:
      • T and B-cells stimulation
      • Stimulation of Ig production
      • Induction of acute phase proteins synthesis
      • Pyrogen 
Q:
Proinflammatory 
IL-12
A:
    • Secreted by macrophages, B-cells and dendritic cells
    • Functions:
      • Th1 differentiation
      • NK stimulation
      • Cytotoxic T-cell stimulation
Q:
Proinflammatory 
Tumor Necrosis Factor 
A:
    • Released by CT-cells, NK cells, macrophages, monocytes and also Th1
    • Function:
      • Induction of apoptosis
      • Induction of local inflammation ( ↑ T)
      • Endothelium activation
      • Chemotaxin for adhesion molecules
Mehr Karteikarten anzeigen
Q:
macrophages function 
A:
  • Phagocytosis → inflammation
  • APC’s
  • Secrete cytokines (IFNα, IL-1) → inflammation
  • Production of lysozyme, complement component and oxygen metabolites 
  • Regulation of cellular functions
  • Production of endogenous pyrogens → fever
  • Repair of tissues 
  • Leukocytosis 
Q:
macrophages IL 
A:
IL-1 
IFN alpha 
Q:
Proinflammatory
IL-1
A:
    • Secreted by macrophages and neutrophils
    • Functions: 
      • T-cell costimulation
      • Induction of TNF (Tumor Necrosis Factor) and IL-8
      • Pyogen (induce fever)
Q:
Monocytes CD
A:
CD 14
Q:
Proinflammatory 
IL-8
A:
    • Secreted by macrophages
    • Functions:
      • Granulocyte activation
      • Main chemokine for neutrophil “calling” (chemotaxis)
Q:

Phagocytosis respiratory burst 

A:

1. increase O2 consumption and glucose 

2. pentose phosphate pathway stimulated for synthesis of NADPH 

3. Produktion of O2 (superoxide anion)-> extremely toxic 

4. Converted to H2O2 (hydrogen peroxide) = oxidizing agent 

5. Production of O2 (singlet oxygen) and OH-(hydroxyl radical) = unstable oxidizing agents

6.Myeloperoxidases : toxic per oxidation of surface molecules > formation of HOCl (hypochlorus acid) 

7. HOcl converted to ClO- (hypochlorite) - very toxic 

8. Exocytosis 

Q:
Anti inflamm 
IL-10
A:
    • Secreted by Th2, monocyte and Treg
    • Functions:
      • B-cell differentiation
      • Th1 and macrophage inhibition
Immunology

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