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major pathway of culling
extravascular (90%
intra is only 10%
as rbc's age, what declines
enzyme
ATP
size
density
destruction of senescent (aged) cells by the spleen
culling
-extra or intravascular
composition of red cell membrane and %
protein 50%
lipid 40%
carbo - 10%
1% of nucleated cell
1-3%
13-30%
1-4%
pronormoblast
basophilic normoblast
polychromatophilic normoblast
orthochromic normoblast and reticulocyte
nutritional requirements
CHON, AA
B12, folic acid, B6
Fe++
RIboflavin, panthotenic acid, nicotinic acid
lipids in external
lipids in internal
phosphatidylcholine, glycolipid, sphingomyelin
phosphatidylethanolamine, p.inositol,p.serine
last stage with nucleolus
basophilic normoblast
large, round to oval, reddish purple
pronormoblast
fx of red cell membrane
separate ICF from ECF
selective passage of nutrient and ion
deformation
round, eccentirc, smaller, more condensed, deeper blue-purple
polychromatophilic normoblast
intensely basophilic
basophilic normoblast
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