Pathology at Batterjee Medical College | Flashcards & Summaries

Lernmaterialien für Pathology an der Batterjee Medical College

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Cervical cancer is the ___ most common cancer in women. This is decreasing because of ____
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Third most common.
Decreasing because of Pap Smear which is a form of early detection
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What are the clinical features of cervical carcinoma?
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1. Abnormal vaginal bleeding
2. Abnormal vaginal discharge, which may contain blood
3. Pelvic pain
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Low oncogenic risk HPVs are the cause of ____
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Sexually transmitted vulvar, perineal, and perianal warts (Condyloma Acuminatum) 
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What are the most common high risk HPVs?
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HPV-16 and HPV-18
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HPVs infect which kinds of cells?
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1- Immature basal cells of the squamous epithelium (in areas of epithelial breaks) 

2- Immature metaplastic squamous cells (at the squamocolumnar junction)
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Where does HPV replicate?
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In maturing squamous cells
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What are the effects of the E6 and E7 viral proteins in Low Risk HPVs?
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E7 binds the RB with lower affinity.
E6 fails to bind P53 and appears to dysregulate growth and survival.

This leads to Benign Warts
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What is the effect of viral proteins E6 and E7?
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They interfere with the activity of the tumor suppressor genes that regulate cell growth and survival.
E6 inhibits TP53 gene
E7 inhibits RB gene
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Which viral protein causes the formation of perinuclear halos?
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E5
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What is koilocytic atypia?
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Nuclear alterations + Perinuclear halos
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Where are koilocytes mostly seen?
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CIN 1
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Which low risk HPVs are especially known to be the cause of condyloma acuminatum?
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HPV-6 and HPV-11
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Beispielhafte Karteikarten für deinen Pathology Kurs an der Batterjee Medical College - von Kommilitonen auf StudySmarter erstellt!

Q:
Cervical cancer is the ___ most common cancer in women. This is decreasing because of ____
A:
Third most common.
Decreasing because of Pap Smear which is a form of early detection
Q:
What are the clinical features of cervical carcinoma?
A:
1. Abnormal vaginal bleeding
2. Abnormal vaginal discharge, which may contain blood
3. Pelvic pain
Q:
Low oncogenic risk HPVs are the cause of ____
A:
Sexually transmitted vulvar, perineal, and perianal warts (Condyloma Acuminatum) 
Q:
What are the most common high risk HPVs?
A:
HPV-16 and HPV-18
Q:
HPVs infect which kinds of cells?
A:
1- Immature basal cells of the squamous epithelium (in areas of epithelial breaks) 

2- Immature metaplastic squamous cells (at the squamocolumnar junction)
Mehr Karteikarten anzeigen
Q:
Where does HPV replicate?
A:
In maturing squamous cells
Q:
What are the effects of the E6 and E7 viral proteins in Low Risk HPVs?
A:
E7 binds the RB with lower affinity.
E6 fails to bind P53 and appears to dysregulate growth and survival.

This leads to Benign Warts
Q:
What is the effect of viral proteins E6 and E7?
A:
They interfere with the activity of the tumor suppressor genes that regulate cell growth and survival.
E6 inhibits TP53 gene
E7 inhibits RB gene
Q:
Which viral protein causes the formation of perinuclear halos?
A:
E5
Q:
What is koilocytic atypia?
A:
Nuclear alterations + Perinuclear halos
Q:
Where are koilocytes mostly seen?
A:
CIN 1
Q:
Which low risk HPVs are especially known to be the cause of condyloma acuminatum?
A:
HPV-6 and HPV-11
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