Coagulation at Bahcesehir University | Flashcards & Summaries

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Lernmaterialien für coagulation an der Bahcesehir University

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TESTE DEIN WISSEN

clotting component/factor - target of action


II (prothrombin) -

VII (proconvertin) -

IX (stuart-Prower factor) -

Protein S & C -

Plasminogen -

Lösung anzeigen
TESTE DEIN WISSEN

II (prothrombin)                  - heparin, dabigatran, warfarin

VII (proconvertin)               - warfarin

IX  (christmas factor, PTC) - warfarin

x (stuart-Prower factor)     - heparin, warfarin, rivaroxiban, apixaban, edoxaban 

Protein S & C                     - warfarin

Plasminogen                      - thrombolytic enzymes, aminocaproic acid

Lösung ausblenden
TESTE DEIN WISSEN

heparin vs. warfarin


structure -

administration -

site of action -

onset -

mechanism -

monitoring -

antidote -

use -

pregnancy -

Lösung anzeigen
TESTE DEIN WISSEN

heparin               vs.          warfarin

large acidic          |        small, neutr

polysaccharide    |       lipid-soluble

parenteral            |              oral

rapid                     |              slow

+ antithrom III       | - post-trans mod F 2,7,9,10

aPTT (unfract)      |     prothrombin time

protamin (unfrct)  |   Kvit, plasma, prothrombin

acute                    |        chronic

yes                       |         no

Lösung ausblenden
TESTE DEIN WISSEN

Which drug combination?

for revascularization 

Lösung anzeigen
TESTE DEIN WISSEN

heparin + thrombolytics

Lösung ausblenden
TESTE DEIN WISSEN

which drug combination?

angioplasty prep

coronary stent placement prep

Lösung anzeigen
TESTE DEIN WISSEN

heparin + glycoprotein IIb/IIIa inhibitors

Lösung ausblenden
TESTE DEIN WISSEN

anticoagulant toxicities



Lösung anzeigen
TESTE DEIN WISSEN

heparin (aPTT) - bleeding, transient thrombocytopenia, osteoporosis

direct thrombin inhibitors (aPTT) - bleeding 

direct factor Xa inhibitors (-) - bleeding

warfarin (PT) - bleeding, hyPERcoagulability w/ dermal necross due to Protein S&C

Lösung ausblenden
TESTE DEIN WISSEN

tissue plasminogen activator toxicities

Lösung anzeigen
TESTE DEIN WISSEN

bleeding

streptokinase induced allergy 

Lösung ausblenden
TESTE DEIN WISSEN

mechanism of anticlotting drugs:

Lösung anzeigen
TESTE DEIN WISSEN

anticoagulants - inhibit fibrin clot formation

thrombolytics - increase plasminogen to plasmin activation

antiplatelet drugs - decrease platelet aggregation

Lösung ausblenden
TESTE DEIN WISSEN

In case of bleeding due to heparin toxicity give ...

Lösung anzeigen
TESTE DEIN WISSEN

protamine

Lösung ausblenden
TESTE DEIN WISSEN

clotting drugs are used in case of 

Lösung anzeigen
TESTE DEIN WISSEN

thrombocytopenia

vitamin K deficiency

genetical clotting problems (hemophilia)

drug-induced conditions

Lösung ausblenden
TESTE DEIN WISSEN

... is a thrombopoietic stimulating factor that is used as clotting drug

Lösung anzeigen
TESTE DEIN WISSEN

oprelvekin

Lösung ausblenden
TESTE DEIN WISSEN

... is antidote for warfarin toxicity

Lösung anzeigen
TESTE DEIN WISSEN

Vitamin K | Phytonadione (vitamin K1)

Lösung ausblenden
TESTE DEIN WISSEN

anticlotting drugs


clotting drugs

Lösung anzeigen
TESTE DEIN WISSEN

anticlotting drugs

a. anticoagulants

   heparin

   direct thrombin inhibitor

   direct factor Xa inhibitor

   warfarin


b. Thrombolytics

   tPA derivativea

   streptokinase


c. Antiplatelet drugs

   Aspirin

   Glycoprotein IIb/IIIa inhibitors

   PDE/adenosine uptake inhibitors


clotting drugs

a.  Replacement factors

b. Vitamin K

c. Antiplasmin drugs

d. Performed clotting factors

e.  Platelet administration

f. Oprelvekin administration

Lösung ausblenden
  • 15175 Karteikarten
  • 247 Studierende
  • 2 Lernmaterialien

Beispielhafte Karteikarten für deinen coagulation Kurs an der Bahcesehir University - von Kommilitonen auf StudySmarter erstellt!

Q:

clotting component/factor - target of action


II (prothrombin) -

VII (proconvertin) -

IX (stuart-Prower factor) -

Protein S & C -

Plasminogen -

A:

II (prothrombin)                  - heparin, dabigatran, warfarin

VII (proconvertin)               - warfarin

IX  (christmas factor, PTC) - warfarin

x (stuart-Prower factor)     - heparin, warfarin, rivaroxiban, apixaban, edoxaban 

Protein S & C                     - warfarin

Plasminogen                      - thrombolytic enzymes, aminocaproic acid

Q:

heparin vs. warfarin


structure -

administration -

site of action -

onset -

mechanism -

monitoring -

antidote -

use -

pregnancy -

A:

heparin               vs.          warfarin

large acidic          |        small, neutr

polysaccharide    |       lipid-soluble

parenteral            |              oral

rapid                     |              slow

+ antithrom III       | - post-trans mod F 2,7,9,10

aPTT (unfract)      |     prothrombin time

protamin (unfrct)  |   Kvit, plasma, prothrombin

acute                    |        chronic

yes                       |         no

Q:

Which drug combination?

for revascularization 

A:

heparin + thrombolytics

Q:

which drug combination?

angioplasty prep

coronary stent placement prep

A:

heparin + glycoprotein IIb/IIIa inhibitors

Q:

anticoagulant toxicities



A:

heparin (aPTT) - bleeding, transient thrombocytopenia, osteoporosis

direct thrombin inhibitors (aPTT) - bleeding 

direct factor Xa inhibitors (-) - bleeding

warfarin (PT) - bleeding, hyPERcoagulability w/ dermal necross due to Protein S&C

Mehr Karteikarten anzeigen
Q:

tissue plasminogen activator toxicities

A:

bleeding

streptokinase induced allergy 

Q:

mechanism of anticlotting drugs:

A:

anticoagulants - inhibit fibrin clot formation

thrombolytics - increase plasminogen to plasmin activation

antiplatelet drugs - decrease platelet aggregation

Q:

In case of bleeding due to heparin toxicity give ...

A:

protamine

Q:

clotting drugs are used in case of 

A:

thrombocytopenia

vitamin K deficiency

genetical clotting problems (hemophilia)

drug-induced conditions

Q:

... is a thrombopoietic stimulating factor that is used as clotting drug

A:

oprelvekin

Q:

... is antidote for warfarin toxicity

A:

Vitamin K | Phytonadione (vitamin K1)

Q:

anticlotting drugs


clotting drugs

A:

anticlotting drugs

a. anticoagulants

   heparin

   direct thrombin inhibitor

   direct factor Xa inhibitor

   warfarin


b. Thrombolytics

   tPA derivativea

   streptokinase


c. Antiplatelet drugs

   Aspirin

   Glycoprotein IIb/IIIa inhibitors

   PDE/adenosine uptake inhibitors


clotting drugs

a.  Replacement factors

b. Vitamin K

c. Antiplasmin drugs

d. Performed clotting factors

e.  Platelet administration

f. Oprelvekin administration

coagulation

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