IP at All India Institute Of Medical Sciences | Flashcards & Summaries

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# Lernmaterialien für IP an der All India Institute of Medical Sciences

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TESTE DEIN WISSEN

Angle of repose:

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Carefully pour powder through the funnel clamped with its tip 2cm above a

graph paper placed on a flat horizontal surface, till the apex of the powder cone thus formed just

touches the tip of the funnel. The mean diameter of the base of the powder cone is determined

and the tangent of the angle of repose calculated using the equation: Tan θ = h/r

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TESTE DEIN WISSEN

PVP

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Polyvinylpyrrolidone

used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. ... The best-known example of povidone formulations is povidone-iodine, an important disinfectant.

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TESTE DEIN WISSEN

Bulkiness

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Reciprocal of bulk density or the specific bulk volume gave the bulkiness.

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The percent compressibility index was calculated using following formula

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TESTE DEIN WISSEN

I= (1 – V/V0) x100

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Hausner’s Ratio

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H.R.=Tapped Density/Bulk Density

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Partition Coefficient:

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TESTE DEIN WISSEN

Add 10 mg aspirin in 50 ml of n-Octanol (pre saturated with water) and

shake it with 50 ml of distilled water (pre saturated with n- Octanol) for 24 hours. After 24 hours

separate both phases and read absorbance. Calculate the concentration in each phase.

Po/w = Coil/Cwater

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TESTE DEIN WISSEN

Particle Size:

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TESTE DEIN WISSEN

Transfer a small portion of the given sample on clean slide and disperse it

uniformly and place the slide on the stage of microscope. Focus the slide to low magnification

(10x). Measure the size of each particle in terms of eyepiece divisions, a total of 100 particles

should be considered, tabulate the particles in terms of division of eyepiece and no. of particles

(frequency) obtained above, classify the diameter into size ranges and average frequency of

particles in terms of no. distribution.

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TESTE DEIN WISSEN

What is disintegration time and how it is tested.

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TESTE DEIN WISSEN
•  What is Disintegration: It is the time required for the Tablet / Capsule to break into particles,
• the disintegration test is a measure of the time required under a given set of conditions (environmental) for a group of tablets/capsules to disintegrate into particles.
• Measured using disintegration tester .
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WHAT IS HPMC?

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HPMC is used primarily in construction materials like tile adhesives and renders where it is used as a rheology modifier and water retention agent.

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Propylene Glycol function

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as a solvent emulsifier

Humectant

Hygroscopic agent

It is clear odorless a liquid whose properties enable it to have pharmacodynamic applications.

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TiO2

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used a pigment, lending whitenewss abd opacity.

lends whiteness

can be uses as opacifier

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IPQC TEST

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IN PROCESS QUALITY  CONTROL TESTS

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Q:

Angle of repose:

A:

Carefully pour powder through the funnel clamped with its tip 2cm above a

graph paper placed on a flat horizontal surface, till the apex of the powder cone thus formed just

touches the tip of the funnel. The mean diameter of the base of the powder cone is determined

and the tangent of the angle of repose calculated using the equation: Tan θ = h/r

Q:

PVP

A:

Polyvinylpyrrolidone

used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. ... The best-known example of povidone formulations is povidone-iodine, an important disinfectant.

Q:

Bulkiness

A:

Reciprocal of bulk density or the specific bulk volume gave the bulkiness.

Q:

The percent compressibility index was calculated using following formula

A:

I= (1 – V/V0) x100

Q:

Hausner’s Ratio

A:

H.R.=Tapped Density/Bulk Density

Q:

Partition Coefficient:

A:

Add 10 mg aspirin in 50 ml of n-Octanol (pre saturated with water) and

shake it with 50 ml of distilled water (pre saturated with n- Octanol) for 24 hours. After 24 hours

separate both phases and read absorbance. Calculate the concentration in each phase.

Po/w = Coil/Cwater

Q:

Particle Size:

A:

Transfer a small portion of the given sample on clean slide and disperse it

uniformly and place the slide on the stage of microscope. Focus the slide to low magnification

(10x). Measure the size of each particle in terms of eyepiece divisions, a total of 100 particles

should be considered, tabulate the particles in terms of division of eyepiece and no. of particles

(frequency) obtained above, classify the diameter into size ranges and average frequency of

particles in terms of no. distribution.

Q:

What is disintegration time and how it is tested.

A:
•  What is Disintegration: It is the time required for the Tablet / Capsule to break into particles,
• the disintegration test is a measure of the time required under a given set of conditions (environmental) for a group of tablets/capsules to disintegrate into particles.
• Measured using disintegration tester .
Q:

WHAT IS HPMC?

A:

HPMC is used primarily in construction materials like tile adhesives and renders where it is used as a rheology modifier and water retention agent.

Q:

Propylene Glycol function

A:

as a solvent emulsifier

Humectant

Hygroscopic agent

It is clear odorless a liquid whose properties enable it to have pharmacodynamic applications.

Q:

TiO2

A:

used a pigment, lending whitenewss abd opacity.

lends whiteness

can be uses as opacifier

Q:

IPQC TEST

A:

IN PROCESS QUALITY  CONTROL TESTS

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