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Angle of repose:
Carefully pour powder through the funnel clamped with its tip 2cm above a
graph paper placed on a flat horizontal surface, till the apex of the powder cone thus formed just
touches the tip of the funnel. The mean diameter of the base of the powder cone is determined
and the tangent of the angle of repose calculated using the equation: Tan θ = h/r
PVP
Polyvinylpyrrolidone
used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. ... The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
Bulkiness
Reciprocal of bulk density or the specific bulk volume gave the bulkiness.
The percent compressibility index was calculated using following formula
I= (1 – V/V0) x100
Hausner’s Ratio
H.R.=Tapped Density/Bulk Density
Partition Coefficient:
Add 10 mg aspirin in 50 ml of n-Octanol (pre saturated with water) and
shake it with 50 ml of distilled water (pre saturated with n- Octanol) for 24 hours. After 24 hours
separate both phases and read absorbance. Calculate the concentration in each phase.
Po/w = Coil/Cwater
Particle Size:
Transfer a small portion of the given sample on clean slide and disperse it
uniformly and place the slide on the stage of microscope. Focus the slide to low magnification
(10x). Measure the size of each particle in terms of eyepiece divisions, a total of 100 particles
should be considered, tabulate the particles in terms of division of eyepiece and no. of particles
(frequency) obtained above, classify the diameter into size ranges and average frequency of
particles in terms of no. distribution.
What is disintegration time and how it is tested.
WHAT IS HPMC?
HPMC is used primarily in construction materials like tile adhesives and renders where it is used as a rheology modifier and water retention agent.
Propylene Glycol function
as a solvent emulsifier
Humectant
Hygroscopic agent
It is clear odorless a liquid whose properties enable it to have pharmacodynamic applications.
TiO2
used a pigment, lending whitenewss abd opacity.
lends whiteness
can be uses as opacifier
IPQC TEST
IN PROCESS QUALITY CONTROL TESTS
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